Sermorelin: A Safe Alternative to Human Growth Hormone

It is well known that the older we get, the more our HGH levels decline. Many people think this natural reduction in growth hormone (HGH) only affects the elderly; however, this decrease in production can begin to affect individuals as early as their 20’s and 30’s. This drops off in growth hormone production often leads to negative physical and emotional symptoms that decrease our quality of life. Fortunately, with the advancement of modern technology it is now possible to treat this low HGH condition (also known as growth hormone deficiency or GHD) without resorting to expensive synthetic versions of HGH. One such treatment is called Sermorelin supplementation. As an alternative to synthetic human growth hormone (HGH), Sermorelin therapy can restore HGH levels to those present during adolescence and early adulthood.

What is Sermorelin?

A Safe Alternative to Human Growth Hormone

Sermorelin is a clinically proven synthetic growth hormone releasing peptide that stimulates the body’s natural production of HGH. It is a non-drug alternative to HGH therapy for people with deficiencies in the pituitary gland’s ability to produce GH naturally. Sermorelin works by stimulating your pituitary gland to secrete human growth hormone (HGH), so you can enjoy its indefinite benefits without experiencing undesirable side effects or complications associated with recombinant human GH injections, such as overproduction of IGF-1 leading to acromegaly.

Sermorelin therapy restores secretion patterns back to those present during early adulthood, reversing the consequences that may arise from low levels of endogenous GH Secretion, including decreased muscle mass, increased body fat, diminished skin elasticity, low energy, loss of libido and depression. Sermorelin is a safe and effective alternative to synthetic HGH injections that restores endogenous GH secretion patterns to those produced during early adulthood.

How does HGH work?

Sermorelin works by replacing the doctor administered GHRH (growth hormone releasing hormone). After an injection of this drug, there is a surge in growth hormone release from the pituitary. This initial pulse of natural growth hormone release stimulates HGH production by the liver/spleen for approximately 30 hours. The increased levels of blood HGH are like levels seen during adolescence and early adulthood when endogenous (internal) GH was more abundant.

What should I expect during my first Sermorelin therapy session?

During your initial Sermorelin therapy session, your physician will consider the following factors: your condition; the effect of any previous treatment; and possible side effects. The variable success rate among patients can be attributed to everyone’s biological make-up and medical history. Generally, the first injection triggers a rapid release of human growth hormone that may last for approximately 30 hours. Subsequent injections should not produce as pronounced or as rapid an increase in HGH production because full pituitary stimulation is achieved within 24 hours and plasma (blood) GH concentrations return to normal by 36 hours after each injection.

How does Sermorelin compare to other treatments for Growth Hormone Deficiency?

The most common treatment for adults with Growth Hormone Deficiency is daily injections of synthetic growth hormone. While this type of therapy restores blood levels to those observed during early adulthood, the resulting high glucose and lipid (blood fat) levels can lead to diabetes and obesity. With Sermorelin Therapy, there are fewer side effects than with synthetic GH because it has a more natural mode of action that results in normalization of IGF-1 without the risk of increased glucose and lipid levels.

Sermorelin is prescribed by physicians who want to restore patients’ endogenous (naturally produced) secretion patterns back to those observed during adolescence and early adulthood. By restoring these endogenous secretion patterns, patients experience better quality sleep and an improved sense of wellbeing.

What are the Benefits of HGH?

Sermorelin is a natural treatment for adults who suffer from low HGH or growth hormone deficiency (GHD). Sermorelin has been shown to provide the following benefits:

1) Increase and improve quality of life and mental well-being.

2) Decrease body fat and increase lean muscle mass, which improves strength and endurance.

3) Improve skin tone and smoothness; reduce wrinkles and fine lines that typically develop with aging.

4) Boost libido, sexual activity, and performance.

5) Restore hair color.

6) Improve vision.

7) Improve cardiovascular health by increasing HDL cholesterol.

8) Reduce blood pressure.

9) Improve sleep.

10) Increase energy levels.

11) Enhance immune function.

Where to inject Sermorelin?

Injected subcutaneously under the skin

Sermorelin should be injected subcutaneously (under the skin) in areas such as the abdomen, lower back/waist, thighs, hips, upper arms, or buttocks. To achieve the best results, focus on areas that have a layer of fat as these are areas that absorb the injections better. Do not inject Sermorelin into muscles as it may cause discomfort and lead to scar tissue formation. When injecting Sermorelin, it is important to rotate injection sites so as not to damage healthy tissue and nerves in any one area.

How is Growth Hormone administered?

Sermorelin must be injected daily using an insulin syringe. Because it naturally stimulates your pituitary gland to release more HGH into the bloodstream, Sermorelin has a high efficacy rate when compared to synthetic versions of GH which require multiple injections per day over several weeks. The injection frequency depends on the individual and there are currently no adverse effects associated with long-term use of Sermorelin so this treatment can continue indefinitely if desired.

What should I expect from Sermorelin?

Sermorelin is a safe and effective way to increase HGH levels in the body. Naturally raised HGH increases lean muscle mass, decreases fat, enhances libido and sexual performance, improves cardiovascular health, reduces wrinkles/fine lines, restores hair color and skin tone, improves vision, boosts energy levels and immune function while improving sleep quality. Sermorelin therapy typically takes six to twelve weeks before showing results. The best time to start Sermorelin supplementation is when symptoms of low growth hormone first appear (such as reduced energy or lack of stamina). This is when your body will benefit the most from treatment.

What is Sermorelin used for?

Used to treat GHD

Sermorelin is used to treat the following conditions:

* Growth Hormone Deficiency (GHD) – Sermorelin is prescribed when the body no longer releases adequate levels of natural growth hormone (GH) on its own. This condition is also known as hypopituitarism or adult growth hormone deficiency (AGHD).

* Delayed Puberty – Sermorelin therapy can be used to treat delayed puberty in children who are not growing and developing at their expected rate. This condition is often caused by a deficiency of growth hormone.

* Short Stature – Sermorelin is usually the first line of treatment for children with an impaired response to GH therapy or those who have idiopathic short stature.

* HIV/AIDS – Research has shown that people with HIV/AIDS experience a decline in growth hormone levels as they age. Sermorelin is used to increase GH levels and correct associated problems such as fatigue, decreased muscle mass, loss of appetite, and weight gain.

How long does Growth Hormone take to work?

Sermorelin is a naturally occurring peptide hormone that stimulates your pituitary gland to release growth hormone (GH) into the bloodstream. It takes at least six to twelve weeks before showing results; this is when you should expect to see the most improvement in muscle mass, energy levels and sex drive.

When to take Sermorelin?

Take your Sermorelin injection daily at around the same time each day. Do not inject the drug any later than 12 hours after you have taken your last dose because it will not achieve optimal results. It is important to maintain a regular dosage schedule as irregular intakes can bring about serious health problems and could result in a complete lack of growth hormone (GH).

What are the side effects of Sermorelin?

Sermorelin has several positive benefits, but it is known to cause the following common side effects in some individuals:

* Headaches 

* Joint pain 

* Rigid muscles 

* Coughing up blood (rare)

These symptoms usually go away after a couple of days and do not require medical attention. Reporting these side effects to your doctor helps us monitor your treatment, modify it if needed and ensure that you receive the best possible care.

What is the normal dosage of Sermorelin?

Common dosage for Sermorelin

Common dosage for Sermorelin is typically between 1-2 IU per day. Your dose is determined by factors such as your age, weight and severity of low growth hormone. The maximum recommended dose is 4IU per day.

Product reviews for Sermorelin:

  1. Joshua Lucas (June 12, 2021): I started taking Sermorelin to treat delayed puberty. My doctor said that I would start seeing results within 6 to 12 months but the improvement in my muscle size and energy levels was noticeable after just 6 weeks. I feel much better now than I did when I was fifteen, which is good because my friends are all graduating college soon, so the next few years are going to be tough.
  2. Michael Smith (July 11, 2021): The daily injections suck but it’s worth it. Once you get past the initial discomfort of giving yourself a shot, what you get in return makes your efforts worthwhile – increased energy and focus during the day and incredible stamina at night! 
  3. Arthur Kelly (July 15, 2021): Sermorelin is the best, I’ve tried it all. It’s very versatile; you can use it to gain muscle mass or simply to reverse symptoms of aging/low growth hormone levels without the side effects associated with synthetic GH treatment (like insomnia). The best part is that Sermorelin works faster than HGH injections and costs less too!
  4. Ethan Mitchell (August 28, 2021): I have been taking Sermorelin for over two years now. I started using it after my checkup when my doctor told me that my growth hormone levels were low due to stress at work. Since starting this therapy, I have noticed a significant change in my energy levels and overall mood – no more mid-day naps!
  5. Eva Green (October 11, 2021): I started using Sermorelin after my yearly checkup. My doctor said that my growth hormone levels were low and recommended this treatment to me. At first, I was skeptical but now I’m so glad that I decided to try it – increased energy is just the tip of iceberg!
  6. Natalie Adams (October 13, 2021): If you want great results without having to go through painful injections for months on end then buy Sermorelin. It takes some time before you start seeing results but it’s definitely worth the wait! 
  7. Tara Ng (October 8, 2021): My ex-boyfriend introduced me to Sermorelin about two years ago and it’s honestly changed my life! I didn’t have any idea about synthetic growth hormone treatments before, but this is way better than taking HGH injections. It’s much cheaper, easier to use and it works faster too!
  8. Jenna Taylor (October 14, 2021): I tried Sermorelin after seeing the positive reviews online. At first, I didn’t think that it would work but now I can’t stop recommending this stuff to my friends! My energy levels are through the roof, and I feel great in general. The only side effect that freaks me out a bit are these weird dreams at night – they are really vivid sometimes – but other than that this is seriously the best medication ever!
  9. Ryan Lopez (October 24, 2021): I’ve been using Sermorelin for almost 10 months now and it’s been life changing. I started taking this stuff because of low energy levels, lack of focus during the day and my doctor said that it would only take a couple weeks to see results! It sounds too good to be true, but I have to say that even though the changes are small at first, they really add up over time.
  10. Jenny Adams (August 26, 2021): I’m a busy mom with 3 kids and a full-time job. Even though I’m always on the go I make sure to use Sermorelin because it has helped me feel better, both physically and mentally! Some people say that the side effects aren’t worth it but for me this treatment was a life changer!
  11. Matthew Cole (March 12, 2021): When my doctor told me about his experience with Sermorelin injections at first, I thought that it’s just another hyped up product by big pharma industry. After reading some reviews online and seeing how much cheaper this stuff is than HGH injections I decided to give it a try and after just one month of treatment I can already tell that my energy levels are through the roof again!
  12. Eva James (April 24, 2021): I’ve been using sermorelin for almost 4 months now and it’s the best thing that ever happened to me. My energy levels are through the roof, my workouts are more intense than ever before, I barely get sick anymore and even lost some weight because of increased focus! It definitely seemed too good to be true at first, but this treatment is legit! 
  13. Ana White (June 11, 2021): I started taking Sermorelin after seeing my doctor for a checkup. My growth hormone levels were low, but he was pretty sure that adding Sermorelin to my treatment plan would help with the symptoms of GH deficiency. After trying this stuff for over two years now – it’s fantastic! I can’t believe that there are still doctors who don’t know about this medication!
  14. Bryan Smith (July 23, 2021): Sermorelin is the best thing that ever happened to me. I started taking it after seeing my doctor for a routine checkup and he said that my growth hormone levels were low. After just one month of treatment with this stuff I already felt more energetic than before. It does take some time before you start seeing results but it’s totally worth it!
  15. Jill White (August 27, 2021): It took me about 2 weeks to see the first results from using Sermorelin but after that point I felt like a new person. My doctor told me that my growth hormone levels were low and that it would take time before they went up again. He wasn’t wrong at all; it does take some time but in my case it really got things going pretty fast!

 FAQ’s about Growth Hormone

Is Sermorelin Safe?

Many users have had great results with this medication and haven’t reported any side effects whatsoever which is why it’s considered one of the best treatments on the market today! However, some people have reported that they have experienced some mild side effects, but these are only temporary and will go away after you stop using Sermorelin. Of course, there are also some rare cases in which people have experienced some more severe Sermorelin side effects, but these are very rare, and no one has reported any case of death from using this medication.

How long will I be on Sermorelin?

Sermorelin usually starts working within a few weeks, after that it could take up until 4 weeks before seeing any improvement. This depends on how low your hormone levels when you started treatment. It’s recommended that this treatment is used for at least 6 months to see the best results!

Is Sermorelin right for me? 

Sermorelin is a safe and effective treatment for people who suffer from Growth Hormone Deficiency. However, if you have been diagnosed with a pituitary adenoma or any other condition which may make taking Sermorelin dangerous for your health consult with your doctor to see if this medication would be right for you! 

Where to buy Sermorelin? 

You can easily buy Sermorelin online and it will be shipped to you within a few days! That way you don’t even need to leave your home and we guarantee that we only provide the best quality products.

Can you take Sermorelin if you are underweight?

It’s not recommended to take Sermorelin if you are underweight because it may cause some side effects and, in the end, you won’t even notice any difference! Eating well and doing some exercise should help with this condition.

How long does a Sermorelin prescription last?

Once you have been treated with Sermorelin, your doctor will generally recommend an evaluation every six months to monitor your progress. In most cases, prescriptions for this medication are valid for up to 9 months but may vary depending on the severity of your condition and how quickly it is diagnosed and effectively treated. Your physician can alter dosage amounts or prescribe additional injections if necessary. However, once treatment has ended physicians generally do not recommend that patients revert to using GH therapy alone – especially if they had previously used synthetic GH in the past.

Who should not take Sermorelin?

There are certain individuals who should not use this medication. For instance, those under the age of 18 or those who have been diagnosed with a pituitary gland tumor or have experienced problems with their pituitary gland in the past should consult a health care professional before using Sermorelin. Pregnant and nursing women may also need to seek advice because scientists still don’t know if it’s safe for them to use the drug.

Sermorelin is totally worth trying out if you want to feel better again!

Sermorelin is a great and effective treatment for people who suffer from Growth Hormone Deficiency. It’s much safer than taking human growth hormone injections which can lead to some very serious health issues. We recommend that you start this treatment as soon as possible because the sooner you start it the better results you will see!

We hope you found this information useful. Remember that if you have any queries, please do not hesitate to ask them below!

Caffeine and Fat Burning

Do you drink coffee? More importantly, do you use coffee to help with your training or performance?

I know there are some people that can’t touch the stuff before training or it results in a trip to the bathroom mid-workout. Personally, I love to sip on a cup of coffee for an early morning workout for a bit of a boost.

But does it help? Specifically with respect to fat burning, does caffeine help? And does it make a difference what time of day you have a cup of coffee in relation to your training?

A recent study looked to answer this question. They wanted to know if caffeine would boost fat burning.

What they did was have the experiment subjects have a drink 30 minutes before an aerobic exercise workout. The subjects included 15 males averaging 32 years old. The subjects did 4 sessions 7 days apart. This allowed them to experience all 4 test conditions of coffee, placebo, 8 AM training or 5 PM training.

The researchers controlled for fasting, exercise and other stimulants consumed. They wanted to make sure the subjects weren’t doing workouts before coming to the lab or slamming back a Red Bull either.

The researchers used indirect calorimetry to measure maximal fat oxidation (MFO).

So what did they find?

MFO and VO2max were greater in the PM than in the AM.

When the groups consumed caffeine there was 10.7% greater MFO in the morning (i.e. 8 AM) compared to the group that consumed a placebo. And with the 5 PM group MFO was 29% greater when caffeine was consumed instead of a placebo.

So the two big takeaways are that:

  1. Caffeine works and helps increase MFO
  2. Results were better with the afternoon versus the morning group

A few things to keep in mind include:

  • Would we see the same results for different ages rather than everyone of approximately 32 years?
  • Would we see the same results for women?
  • Would we see the same results for sedentary individuals? All the participants in this study were already active.
  • Would the results have differed if more caffeine was consumed? The subjects consumed 3 mg/kg bodyweight. So an 80 kg individual would ingest 240 milligrams of caffeine. (a cup of coffee has about 100 mg)

Lastly, don’t lose sight of the fact that the best time to exercise is when you can make time for it. Different chronotypes do better at different times of day. And although afternoon caffeine resulted in more MFO compared to the morning don’t forget of the fat burning powers of sleep. If an afternoon cup of coffee disrupts sleep it may not be worth it.

Ramírez-Maldonado, M., Jurado-Fasoli, L., Del Coso, J., Ruiz, J. R., & Amaro-Gahete, F. J. (2021). Caffeine increases maximal fat oxidation during a graded exercise test: is there a diurnal variation?. Journal of the International Society of Sports Nutrition18(1), 1-9.

Obesity to Become Main Cancer Risk

Growing up we always associated smoking with cancer. We’d have the school assemblies to prevent us from lighting up. The packages of cigarettes had images of disgusting gum and tooth disease caused by smoking. And we all knew a relative or loved one that was a smoker and passed away from cancer.

That could all change.

Obesity could overtake smoking as the main cancer risk by 2040 in women and soon after in men.

And with the pandemic this isn’t getting any better. Since this time last year most people have put on a few pounds, are less active and eating more junk food. And when the food delivery services show up in our neighbourhood it’s usually bringing fast food. Combine this with more people quitting smoking and it’s easy to see how obesity will overtake smoking as a greater risk for cancer.

So what’s the big deal with obesity?

Well fat isn’t inert tissue that gets added to the body and has no effects. It doesn’t just sit there quietly but is active. It sends signals to other tissues and organs that affect growth, metabolism and reproductive processes.

When we are obese we are vulnerable to tissue damage and developing tumours. And there are least 12 types of cancer linked to carrying excess weight. Regular exercise is important for cancer prevention specifically breast and colon cancer.

A recent study in the UK involved exercising mice three times per week for 30 minutes. These mice showed lower levels of inflammation, which can lead to the development of tumours. As well, the mice that exercised improved their metabolism, had less fat in their livers and moved more quickly.

In the UK there are 135,000 new cancers per year (about 4 in 10) deemed to be preventable. Exercise can be a great way to reduced the chance of obesity and thus lessen the chance of developing cancer.

Bianchi, A., Marchetti, L., Hall, Z., Lemos, H., Vacca, M., Paish, H., & Wilson, C. L. (2021). Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis. The Journal of Immunology206(4), 904-916.

Answers to all of your questions about creatine

After high school I remember training with my brother. And the goal wasn’t to improve performance in a sport. And it wasn’t to sprint faster. Or to rehab an injury.

It was purely for bodybuilding. We trained to get as big and strong as possible with more emphasis on the former.

And while we didn’t invest a dime into programming or coaching we always found it in the budget to have a tub of protein, some bars and creatine.

So while creatine has been available commercially to the average gym goer for over 30 years there are still a number of myths regarding this supplement. Some of the top supplement researchers and editors of the Journal of the International Society of Sports Medicine collaborated to put out a review of the more common questions that exist about creatine. The following is a brief summary of this review with the citation to follow.

Does creatine lead to water retention?

Researchers will distinguish between total body water (TBW), intracellular water (ICW) and extracellular water (ECW). Most studies do not show an increase in TBW. When loading creatine this is usually done at higher doses than during the maintenance phase and early research showed some water retention but didn’t distinguish between ICW and ECW.

The general understanding is that there is some evidence of water retention, primarily ICW, over the short term. Several studies show creatine doesn’t alter TBW (ICW or ECW) relative to muscle mass.

Does creatine damage the liver or kidneys?

After more than 20 years of research there are no adverse effects from taking the recommended dosage of creatine. Creatine and phosphocreatine are degraded to creatinine. The amount of creatinine in the blood is proportional to body mass and creatine intake.

There was a case study from the late 1990s when an individual did experience elevated levels of creatinine and usage was discontinued for this reason. Apparently this individual had previous renal/hepatic issues and was loading at 15 g per day. The case study makes no mention of the diet of the individual which can contribute to elevated levels of creatinine.

For healthy individuals, ingesting normal dosages, there are no known adverse effects for the kidneys or liver.

Does creatine cause dehydration or cramping?

During the loading phase of 20 g/ day for 5-7 days there may be an increase in body mass of 1-3 kg, which is mostly body water retention. The studies that do show dehydration/cramping don’t control for other supplements and beverages.

As well, a study looked at how many creatine users use the recommended daily dose and found 91% exceeded these amounts.

Another study had subjects put into two groups. 38 of them took creatine and another 34 took a placebo. Those that took creatine had less cramping, heat illness, dehydration, tightness, muscle strains and injuries.

And a study involving haemodialysis patients (n=10) that reported frequent cramping were given 12 grams of creatine before haemodialysis and saw a decreased frequency of cramping by 60%.

The take home message is the creatine does not appear in the research or anecdotally to result in cramping or dehydration.

Does creatine increase fat mass?

Whenever a substance is known to increase body mass, as creatine does, there may be concern for an increase in fat mass. This concern may be justified in that rarely do we add 100% muscle mass and zero fat mass when we increase our mass.

The literature is pretty clear and consistent on this however. There are numerous studies showing an increase in body mass, an increase in fat free mass yet no increase in fat mass. One study with swimmers showed no change in body composition.

A common criticism of the studies showing no increase in fat mass is that they are less than 8 weeks in duration and thus not long enough in duration to demonstrate a physiological change. There are more than enough studies greater than 8 weeks which show no significant change in fat mass.

Of interest was a study involving children with lymphoblastic leukemia. For 16 weeks some of the children received creatine and the others a placebo. Those taking creatine saw their fat mass decrease while those that didn’t take it saw an increase in their fat mass.

Supplementing with creatine may increase body mass without increasing fat mass.

Is a loading phase required?

If you’re familiar with using creatine as a supplement you’ll know there’s something called a ‘loading’ and a ‘maintenance’ phase. The loading phase involves taking creatine at 20-25 grams per day for 5 to 7 days to saturate the muscle. Once the loading phase is complete then the maintenance phase follows at doses of 3-5 grams per day.

A study compared loading versus simply going to the maintenance phase and determined that both resulted in an increase of muscle creatine concentrations by 20%. Loading speeds up the process but doesn’t add any additional benefits. Going straight to a loading phase delays but doesn’t limit the benefits of using creatine when used for at least four weeks.

When an athlete is looking to benefit from creatine in a short period of time i.e. less than 3 weeks, than a loading protocol would be preferred. If creatine will be used for a longer duration i.e. at least four weeks, than it would be fine to go straight to a maintenance phase, especially if avoiding or minimizing the increase in body mass is desirable.

Is creatine just for power or resistance athletes?

We know that creatine is a phosphagen and helps supply and replenish cellular energy for short burst, high intensity activities. So typically it has been sought out by athletes that need to display high levels of force in a short period of time. This would include sprinting, jumping, throwing and kicking among other actions.

But does creatine help other athletes and functions?

There is growing evidnce to suggest that it is. For example, when creatine is taken with carbohydrate or carbohydrate with protein there is greater glycogen storage compared to carbohydrate alone. Glycogen is the form of carbohydrate that we store in the muscle and liver and is important for training and recovery.

Those that supplement with creatine show less muscle damage and in a four week study with runners training up to 30 km those taking creatine experienced less muscular damage, inflammation and soreness.

Lastly, creatine appears to offer protective benefits to the brain and spinal cord and may be a good idea for those in collision sports and at risk for concussion.

Creatine offers many benefits and need not be limited to only those in power or resistance sports.

Below is a summary of each of the sections of the review. For more details and to read the sections not covered above see the citation below. The section below in italics is copied directly from the review.

Based on our evidence-based scientific evaluation of the literature, we conclude that:

  1. Creatine supplementation does not always lead to water retention.
  2. Creatine is not an anabolic steroid.
  3. Creatine supplementation, when ingested at recommended dosages, does not result in kidney damage and/or renal dysfunction in healthy individuals.
  4. The majority of available evidence does not support a link between creatine supplementation and hair loss / baldness.
  5. Creatine supplementation does not cause dehydration or muscle cramping.
  6. Creatine supplementation appears to be generally safe and potentially beneficial for children and adolescents.
  7. Creatine supplementation does not increase fat mass.
  8. Smaller, daily dosages of creatine supplementation (3-5 g or 0.1 g/kg of body mass) are effective. Therefore, a creatine ‘loading’ phase is not required.
  9. Creatine supplementation and resistance training produces the vast majority of musculoskeletal and performance benefits in older adults. Creatine supplementation alone can provide some muscle and performance benefits for older adults.
  10. Creatine supplementation can be beneficial for a variety of athletic and sporting activities.
  11. Creatine supplementation provides a variety of benefits for females across their lifespan.
  12. Other forms of creatine are not superior to creatine monohydrate.

Antonio J., Candow D.G., Forbes S.C., Gualano B., Ragim A.R., Kreider R.N., Rawson E.S., Smith-Ryan A.E., VanDusseldorp T.A., Willoughby D.S. & Ziegenfuss T.N. (2021). Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? Journal of the International Society of Sports Nutrition, 18(13).

MOTS-c – The Fountain of Youth Protein

When I think of longevity a couple of movies come to mind. Cocoon and The Curious Case of Benjamin Button cover this theme in different ways.

Or a quick history lesson takes us back to Ponce de Leon and the search for the fountain of youth.

Researchers at USC may have found the protein that confers anti-aging benefits.

The protein is MOTS-c and is a mitochondrial protein. Mitochonria can thought of as the powerhouse of the cell and are responsible much of our cellular energy. MOTS-c acts by heping promote metabolism amd maintaining homeostasis.

Previous research into MOTS-c has shown that it helps increase insulin
sensitivty and reverse obesity in mice.

In human when we exercise we see the level of MOTS-c is elevated almost 12x and remains elevated for up to four hours post-exercise.

What the research team at USC did was inject MOTS-c into mice of various ages and then measure their speed and agility, among other things. For mice, young is considered 2 months old, 12 months is middle age and old is 22 months.

The researchers injected the mice three times per week and had them perform a running test. The mice would warm-up for 5 minutes at 13 metres per minute. After five minutes the speed was increased one metre per minute for five minutes to reach 18 metres per minute. The mice then ran for up to 30 minutes at a top speed of 23 metres per minute.

What they found is the older mice i.e. 22 months old, were able to keep up and outrun the young and middle aged mice. As well, the older mice were more sure-footed compared to the younger mice.

This is encouraging and it appears MOTS-c may play a role in healthy aging. It helped with the metabolic fitness and physical capacity of the mice in this study. And MOTS-c was also able to reverse diet induced obesity and insulin resistance in mice as well.

While we shouldn’t expect the same results in humans as in mice this is more support regarding the importance of maintaining fitness and training as we age. This will not only allow us to have more years but a better quality of life with the years we add.

Reynolds, J. C., Lai, R. W., Woodhead, J. S., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., & Lee, C. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications12(1), 1-11.

Muscle Cells Attenuate Effects of Inflammation

Have you ever had one of those situations in life where somebody asks you a question of why something is and you can’t put into words the explanation.

For example, imagine a young toddler asking why is the sky blue?

What would you say? How would you explain it?

It’s something we know to be true but hard to put into words.

The same could be said for the benefits of exercise. We have known for a while that exercise helps with inflammation. But we didn’t know which cell type(s) were involved? And could this help maintain strength?

A research team at Duke University has been looking to answer this question. Specifically they wanted to see how effectively muscle cells would be at warding of chronic inflammation. This is different from acute inflammation that results from a specific episode such as a sprained ankle. When we roll an ankle playing pick up basketball there is an immune response to clear away cellular debris and helps the tissue heal.

Other times inflammation can extend over long periods of time causing damage and weakening tissues i.e. rheumatoid arthritis and sarcopenia. This type of chronic inflammation induces muscle atrophy. Exercise can counter these negative side effects.

The researchers were able to engineer muscle cells in-vitro i.e. in a petri dish. These cells were then exposed to interferon gamma for seven days. We normally see this chemical messenger elevated in muscle cells of those with chronic inflammation.

After the seven day period of exposure to interferon gamma, to induce a situation of chronic inflammation, the researchers then stimulated the muscle cells electrically to make them contract.

What they found was that the muscle cells that exercised i.e. that were electrically stimulated, did not show the effects of chronic inflammation. With long term inflammation, i.e. chronic inflammation, there is atrophy, or loss, of muscle tissue. This did not happen with the muscle cells that were electrically simulated.

What’s even more interesting is that the experiment only involved muscle cells. Typically we might associate health benefits with immune, stem or other type of cell. This is a new discovery of linking the protection from inflammation directly to muscle cells.

And as the images below show, exercise helps prevent the atrophy of muscle that typically is associated with chronic inflammation. If you stay active, particularly with resistance exercise, your muscles won’t get smaller and weaker.

The top L box shows muscle cells (red) in the control condition. In the top R we can see how inflammation changes the structure of the muscle cells. However in the bottom L adding exercise to the mix protects the muscle cells from the damage of inflammation.

We can train for a variety of reasons and this adds another very important reason to make sure we lift weights. This is especially true for those that suffer from inflammatory diseases such as asthma, celiac, diabetes, rheumatoid arthtitis, obesity and more.

Chen, Z., Li, B., Zhan, R. Z., Rao, L., & Bursac, N. (2021). Exercise mimetics and JAK inhibition attenuate IFN-γ–induced wasting in engineered human skeletal muscle. Science Advances7(4), eabd9502.

Go Hard or Go Frequently?

The other night at dinner we asked our five year old the question of which came first, the chicken or the egg?

She thought about it briefly and then answered confidently saying the egg.

To which we then asked her where the egg came from?

You can imagine the puzzled look on her face and could see the wheels turning in her head. She realized she it was going to be a hard question to answer.

This can be similar to exercise with respect to whether you should do long, slow steady-state exercise or short, high intensity intervals. The last few years have seen a surge in HIIT i.e. high intensity interval training, Tabata and other intense training protocols.

However during COVID we have also seen a number of endurance feats including Everesting, round the world cycling challenges and other long distance endurance challenges.

So which one is it? Should we go hard and short or long and slow?

Well a recent Canadian study looked to answer this question. Here’s what they did.

Twenty three adult, sedentary men were divided into two groups. One group did 30 second sprint intervals on the bike with two minutes rest. They repeated this four to six times and completed this workout three times per week. Over the course of the six study they completed almost one hour of cycling.

The other group rode the bike five times per week for 30-40 minutes at around 60% of their peak power. By the completion of the study this group had logged 15 hours on the bike.

Researchers wanted to know the impact these would have on fitness, body composition and blood pressure.

What they found is that those performing the endurance workouts i.e. 30-40 minutes of cycling saw greater improvements in:

  • diastolic blood pressure
  • abdominal fat
  • postprandial lipid tolerance

Both groups showed improvements in fitness whereas with the sprint group improved endothelial function. With both groups glycemic control was better on exercise versus sedentary days.

So what does this all mean?

Don’t get sucked in to the fad that exercise has to all-out, all the time. There were a number of benefits to performing longer duration cardiovascular exercise. Exercise is great for helping us metabolize carbohydrates and avoid the potential spikes and drops

A few other thoughts that come to mind:

  • This study was all men. Would women show the same results?
  • Endurance training demonstrated many benefits in this study. But they also did 15 times the work. Would the same benefits be seen at 10 times the work? 5 times?
  • All participants were sedentary at the start. How hard were they able to push on the sprints? How would the results differ if active subjects were used? If athletes were used?
  • Time is a huge constraint for many to achieve a fitness and health goal. We shouldn’t discount or over-look the attractiveness of being able to complete training in 1/15th of the time.
  • Ultimately the best training plan may be a combination of high-intensity short duration intervals and lower-intensity longer training sessions.

Citation

Petrick, H. L., King, T. J., Pignanelli, C., Vanderlinde, T. E., Cohen, J. N., Holloway, G. P., & Burr, J. F. (2020). Endurance and Sprint Training Improve Glycemia and VO2peak, but only Frequent Endurance Benefits Blood Pressure and Lipidemia. Medicine and Science in Sports and Exercise.

More Frequent, Intense Exercise Is Better

I remember when I was young I had a swim meet on the weekend. But the meet wasn’t due to start until the afternoon. And so I asked my dad if he wanted to go play tennis. And he said no and that I should probably rest before my meet rather than go and play tennis.

And this was probably a good idea. I was able to rest up and focus on my races to come.

But I find it interesting how the frequency and intensity of our exercise changes as we grow up from childhood, through adolescence, into our teens and eventually as adults.

When we were younger we thought nothing of having swim practice in the morning, playing football at recess and lunch, followed by swim practice again in the evening. And if there was time we’d fit in some more time to play with our neighbourhood friends.

Now if most of us do one activity in a day we’re spent for that day and possibly for days after. One client and friend, LM, enjoys going cat and heli skiing. He says that he tends to have to ‘fake sore’ with the rest of the group on the trip regarding his fatigue and DOMS (i.e. muscle soreness). Everyone else is suffering after an intense day of carving powder and so he ‘fakes sore’ in order to fit in.

But how much exercise is enough? And hard should we push ourselves?

A new study out of Oxford tells us that more is better when it comes to exercise. And the benefits were greater with more intense exercise.

Here’s what they did.

Researchers observed the fitness habits of over 90,000 adults, both male and female. And they wanted to see the impact of exercise intensity and frequency on cardiovascular (CV) health. CV disease is the number one cause of death and so it makes sense to see the impact exercise has on it.

Previous studies of this type would involve participants self-reporting their exercise. This can sometimes be flawed as we may over-estimate the duration and intensity of training. To overcome this researchers had the participants wear an accelerometer on their wrist.

What they found is that those getting the most frequent and intense exercise had the greatest reduction in CV risk. Those in the top 25% doing vigorous exercise saw their risk for CV disease lowered by 54-63%. On a scale of 1-10, vigorous exercise would fall at about a 6 or 7 out of 10. Or if you use a heart rate monitor this might be about 70-85% of your maximal heart rate.

And if the exercise wasn’t vigourous there were still great benefits to be had. Exercise at a moderate intensity showed reductions in CV risk factors by 48-57%. So even this group is cutting their CV risk in half. Moderate exercise on a perceived effort scale would be about a 3 out of 10 or 50-70% of your maximal heart rate.

The benefits seen applied to both men and women however the results for women doing vigourous exercise were particularly strong.

As well, those more likely to exercise were also:

  • less likely to smoke
  • more likely to maintain a healthy weight
  • more likely to consume a moderate amount of alcohol

The take home message is that it’s OK to exercise ever day. Think back to when you were a kid or watch a new puppy. Sure they may sleep a lot when first born but after a while they play a lot. And they go all out.

Our risk for CV disease only increases as we age yet we get less of what protects us from this disease. If you are not sure how to get started, or if your exercise is intense enough or would like some help to increase the frequency and intensity of your exercise leave a comment below or stop in to Okanagan Peak Performance Inc.

Ramakrishnan, R., Doherty, A., Smith-Byrne, K., Rahimi, K., Bennett, D., Woodward, M., … & Dwyer, T. (2021). Accelerometer measured physical activity and the incidence of cardiovascular disease: Evidence from the UK Biobank cohort study. PLoS medicine18(1), e1003487.

Spotlight on Derek Retzloff

Hello! How’s it going? It’s Trevor here and I’ve got a great success story to share with you.

This story is about Derek Retzloff, and he has achieved some amazing results over the past 2 months with his training.

Derek rocking his Seahawk Air Jordans.

You know Derek, right? Or better known to you as Derek Scott, the radio guy from SunFM (now Virgin).

He might not look familiar but if you heard his voice on the radio, I’m sure you’d recognize it.  Derek is usually in at 9:30 am Monday, Wednesday and Friday. He has done numerous works for SunFM and other radio businesses for over 20 years. For a person who has had to face numerous challenges throughout life, it makes what he’s achieved even more amazing.

From a young age, Derek was at a physical disadvantage. His so called “condition”, which he’ll describe for you shortly, made certain tasks of daily living challenging. Tasks weren’t necessarily impossible to complete, but hard to be efficient. It might be tough to relate but consider the things you’ve struggled with in your life and eventually overcame. Maybe you broke your leg, tore or pulled a muscle, hurt your back and had to sit out from a sporting event or even had to take time away from work. You were presented with new challenges in your daily life, but eventually you got better and were back to health.

Remember how those challenges made you feel? Even better, how you felt when you accomplished them? Imagine if you had to live with them your whole life and each day there was something to accomplish. Sooner or later you work through those challenges more fluently and now you’re looking for even more ways to challenge yourself. You won’t let anything stop you or get in your way. That’s Derek for you. Each day he accomplishes something in one way or another. He accepts and embraces all obstacles in life as an opportunity for improvement. If anything, it’s all fun and games to him!  

Now, before I continue to ramble on about Derek and what he’s achieved in a short amount of time, I should back up, and have him tell you himself.

Here’s his story.

Trevor: Give us a background on your surgery and how you’ve carried yourself over the course of your life?

Derek: When I was born and throughout most of my young life, my doctors thought I had something called Charcot Marie Tooth disease, which affected my legs.  I had many heel cord lengthening surgeries and muscle biopsies to try and figure out what was going on. But when I turned 18 the medical system essentially gave up, and I was left undiagnosed.  The results of these surgeries didn’t really prove or help anything, but back in the 80’s surgery was the answer to everything.  I can remember one visit to the doctor, I was told I could end up paralyzed and could lose the use of my hands.  Thankfully that never happened. 

Even with all of this going on, I was always a happy little guy.  I would have been an easy target for bullies and such at school, but thankfully, I always had a great group of friends who looked out for me. Even a few of the bad kids too. 

When my Dad started seeing a massage therapist, he mentioned my situation to her, and that’s when I started with regular massage therapy. I really started to feel a difference.  I was told that my legs were like two cement poles with no muscle definition at all, but that all changed thanks to her.  My whole medical history was a lot of guessing and tests. When I got older, I figured out that I could change things.  Little things happening in my life that led me to believe that I could do more than I a could.  That’s why I have so much fun at Okanagan Peak Performance Inc. They push me every day to do better and make me feel comfortable while having fun.  Not only do I feel better, but I get to learn how certain exercises work and how they transfer to my everyday life.

Trevor: What are some of the challenges you’ve had to face in your life? Could be day-to-day, things that you may have missed out on or really wanted to do.

Derek: Certain things in my life have always been a challenge. I’m now at the point where I don’t even consider them because I’ve come to accept it.  For example, I have a tough time with steps.  I need a handrail to go up a set of steps.  If I want to go to a sporting event or the movie theater, I need to make sure there’s a railing to hold on to, or it’s just not happening.  That could be looked at as a downside, but I choose to look at it as a positive. It means that I can use the disabled section and get a much better seat full of room. 

I’ve always chose to look at the positives and not think negatively about things.  I think that’s just the way I was brought up.  My parents always taught me to be strong, smart, and to always try my best.  I was in casts from the time I was a little guy, but still I was on my bike (two casts on my feet) and sailing over ramps.  When I was in school things were a bit more challenging.  I wanted to play sports with my friends, but obviously it was tough for me.  I still did play, but I couldn’t run or stay on my feet for very long. 

I can remember one time when I was playing on the basketball team in junior high. My coach had me wait at the other end of the court until we had possession.  Once my teammates were close, they would pass it to me.  I tried out for the team and didn’t think I was going to make it.  I was surprised when I did.  Years later, I realized that the coach didn’t want to cut me and let everyone else play. He was trying to be inclusive.  This might seem “okay” to some, but that’s when I realized I wasn’t going to be “that guy” and be made a spectacle of.  

While the game was happening at the other end of the court, people in the stands would be staring at the guy all by himself with the skinny legs. It really made me feel different.  My coach’s intention was to have everyone become a star, and that’s when I realized I didn’t have to be like everyone else.  I quit the team shortly after and felt like I learned a valuable lesson. 

To this day, I know my limits, but that’s all from trying things myself and getting feedback.  Aside from these little things, I really don’t feel much different from anyone else.  At 40 years old, there are plenty of things I don’t want to do anymore, and I’m more than happy with that.  I should mention that I also played competitive wheelchair basketball for many years, and even managed to play for Team Alberta in the Canada Games.  I won a few medals and met a lot of great people. 

I’ve also been involved in the radio industry for over 20 years. I’ve met some of the most popular musicians in the world and have done a lot of very cool things.  My disability had nothing to do with that, that was all me.  That just goes to show that my disability doesn’t define me, it’s just something that adds to the person I am.  I believe that a person can be defined by something and let it defeat them, or you can recognize the challenge, address it and deal with it.

Trevor: Tell us about the huge WIN you had. 

Derek: I have such a great time training with Trevor each day. I told him after one of our first sessions that I felt bulletproof when I walked out of the gym.  I still feel that every day.  Not just at the gym but in everyday life.  Little things, like picking something up or having more stamina when I’m out walking around.  Due to my disability, I pretty much always need to sit down.  I compare it to an hourglass.  From the time I stand up, turn it over, I’m going to need to sit down shortly after.  That’s just something I’ve come to accept. 

Usually, wherever you go, you can find a bench or somewhere to sit down, but with Covid, those benches and seats have been taken away.  I can recall a trip to the mall recently where I walked from my vehicle, all the way to the back of the store, and then had to wait in 2 lineups. I got all the way back to my Jeep and wasn’t tired.  It was something that hadn’t happened to me in a long time.  That’s thanks to Trevor, Chris and everyone at OPP, but also thanks to me.  I’m not ashamed to say I’m proud of myself, or that it was easy to do because it wasn’t. 

 I work hard at the gym and I love seeing the results of my hard work.  I also want to mention as a result of the benches disappearing, I bought a walking cane for long periods of standing but have never used it.  If I decided not to take my fitness seriously, change my eating habits, and focus on myself, I’d be worse off.  Aside from my wheelchair basketball successes, I’ve never really considered myself an “athlete”.  I know it’s just a word, but it makes me feel special. 

When I get Chris’ emails calling us athletes and peak performers, it makes me smile.  One of the things I love and respect so much about OPP is that, never for a single second have they made me feel different, or like I couldn’t accomplish something.  Thanks to their extensive knowledge, they’ve set me up with a program that works for me and makes me feel great.  It can be intimidating in other gyms when you have skinny legs, or need assistance from a bar to stand up, but at OPP I’ve never felt that way.  Trevor has been such a great coach in recognizing what I can do and always pushing me to do “one more” or try just a bit more weight.  It makes me feel so good to push a little more, go a little bit faster, or dig deep for that last ounce of energy.  I don’t just feel it, I AM bulletproof!

Trevor: How have you been able to achieve these goals? And what are you looking forward to in the future?

Derek: I can’t say enough great things about Chris, Harry, Trevor, other staff members and OPP in general.  I also know a huge part of it is me.  I’m the one responsible for myself and if I don’t do all the things it takes to make my training effective, that’s on me.  I was that guy who always said, “I don’t want to go to the gym”, or, “yeah one day I might give it a shot”, but that all changed.  As strange as it sounds, I’m almost happy that COVID came. It gave me a lot of time to sit and think about myself and what’s important to me. 

I didn’t eat a lot of fast food, but I did eat more than I probably should have.  I want to get rid of my cheeseburger locker (tummy) but know that it’s going to take a lot of work to do so. Especially in my late 30’s.  I decided that if I was exercising but still eating the bad stuff, my training really wasn’t going to make much of a difference.  Just making little changes here and there, I started to notice some positives. 

I’ve only been at it for about a month and a half, but I’ve already noticed that my biceps are rock hard. I’ve got some muscles on the sides of my tummy that I never had before, and thanks to my trip at the mall, my endurance and stamina has increased big time.  As daily activities become less tiring, it takes longer for that to happen, and I’ll call that a huge win.  As I continue my training, I hope to continue improving my full body strength and stamina, so little things like steps, or tying my shoes aren’t so difficult.  As great as our coaches are, it’s ultimately up to us as athletes to work our hardest and to get the most out of our coaching.  And hey, what investment is better than yourself?!

Thanks.

Trevor: I hope you’ve enjoyed the read so far, and hopefully you have a couple more minutes to listen to what I’m most proud of Derek for. You’re already aware of how hard Derek works and what he’s accomplished with his training. Instead, let me tell you what he does for me and the rest of us at OPP.

From the moment he rolls up in the parking lot, a wave of energy spreads through the facility. He always walks in with a smile from ear to ear and can’t wait to be the first one to say “hello”. He’s a spark. What I mean by that is, his positive attitude and friendliness projects on to the people around him. Whether it’s chatting about football (he is a huge Seahawks fan), hip hop, daily adventures, or his low-key obsession for Jordan shoes, the conversations are endless. Looking back on our first couple weeks together, we didn’t chat as much. It’s kind of funny now, but he was always trying to catch his breath from the previous set. Since that’s gone, there is more time for chit chatter, and don’t get me wrong, when it’s time to work it’s time to work! He continues to improve strength, endurance and competence each week. Keep bringing that A-level effort day in and day out!

All of us at OPP are so proud of what Derek has achieved in such a short amount of time. When you have a moment, take some time to reflect on the things you do everyday. Where can improvements be made? And how can you get the most out of each day?  

Well done Derek! And thanks for sharing.

Training While Injured to Prevent Muscle/Strength Loss

There’s an expression in sports that ‘you play, you pay’. And this refers to getting injured.

You play frequently enough and push yourself enough and you will suffer an injury. It’s not a case of ‘if’ but ‘when’.

Most athletes know what I’m talking about and have spent time in an ER, in a sling, on crutches or a wheelchair. I’d have to say being injured is the worst part of sports. Worse than losing.

Because when you’re injured you can’t play. You can’t help your team. And if things aren’t going well it’s even worse. You have to wait it out, go for your rehab appointments and wait for the OK to return to training and competition.

A recently study looked at how training the non-injured side minimized the losses that typically occur to the injured side.

What the researchers did was have 30 subjects, male and female, between 18-34 years, put their non-dominant arm in a sling for 8 hours per day. The elbow was bent to 90 degrees and then immobilized for the 8 hours. The non-dominant arm was determined as the non-writing arm.

All subjects had the non-dominant arm immobilized for 8 hours per day.

The 30 subjects were then assigned to one of three groups. The first group did no exercise, the second did eccentric and concentric exercise and the third group did eccentric only exercise. The tempo for the eccentric and concentric group was 2 seconds up and 2 seconds down. And for the eccentric group the participants took 4 seconds to lower the weight. The exercise performed was a biceps curl over a preacher bent with a dumbbell. For the eccentric only group the researcher grabbed the dumbbell at the bottom of each rep.

Participants did 3-6 sets of 10 reps of dumbbell preacher curls for 4 weeks.

For the next 4 week the subjects performed this exercise 3 times per week with 3-6 sets of 10 reps. For the eccentric and concentric group the loads ranged from 60-90% and for the eccentric group the loads ranged from 80-120%. For both groups the loads increased 10% each week.

The researchers wanted to see the impact this would have on arm circumference, one repetition maximum strength (1 RM), maximal voluntary isometric contraction, rate of force development and joint position sense.

So what did they find?

The group that did no exercise lost the most muscle and in this case they lost 28% of their arm muscle mass. The two exercise groups lost less strength and arm size with the losses being less with the eccentric only group. In fact, the biggest increase in strength was with the eccentric only group and there was only 2% muscle wastage in the immobilized arm.

Besides injured athletes this research is also valuable for those who have suffered a stroke. If you find yourself unable to exercise one limb make sure to continue with the exercise. But don’t just do any type of exercise as in this case eccentric only training did the best job of maintaining strength and minimizing losses.

Valdes, O., Ramirez, C., Perez, F., Garcia‐Vicencio, S., Nosaka, K., & Penailillo, L. (2021). Contralateral effects of eccentric resistance training on immobilized arm. Scandinavian Journal of Medicine & Science in Sports31(1), 76-90.